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Key Features Onset: Usually 28 weeks after starting the offending drug Symptoms: Fever Widespread skin rash (morbilliform, exfoliative, or pustular) Facial edema Lymphadenopathy Multi-organ involvement (especially liver, kidneys, lungs, heart) Common Causative Drugs Anticonvulsants: Phenytoin, Carbamazepine, Lamotrigine, Phenobarbital Antibiotics: Sulfonamides, Minocycline, Vancomycin Allopurinol Dapsone Laboratory Findings Eosinophilia Atypical lymphocytosis Elevated liver enzymes Abnormal renal function tests Diagnostic Criteria (RegiSCAR) 1

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